Genetic Variants Found That Increase Risk of Endometriosis

Genetic Variants Found That Increase Risk of EndometriosisA new study has claimed to find two genetic variants that play their part in aggravating the risk associated with the occurrence of endometriosis in women.

The Nature Genetics study led by researchers from the University of Oxford, the Queensland Institute of Medical Research in Australia and Harvard Medical School, Boston by finding the indicators of development of endometriosis has opened way to the more effective treatments and diagnosis.

In the study, analysis was conducted on the genomes of 5,500 women from the UK, US and Australia suffering from the condition and the results were compared with 10,000 those women who were keeping good health.

The two genetic variants found were - chromosome 1 and chromosome 7, which were significant in increasing risk of endometriosis in women. Chromosome 1 is similar to a gene that is crucial for hormone metabolism and helps in the development of the female reproductive tract. On the other hand, chromosome 7 is associated with the regulation of genes that develop the womb and its lining.

About 6-10% of women in their reproductive years get affected with Endometriosis, which is a common gynaecological disease.

"Our study is a breakthrough because it provides the first strong evidence that variations in DNA make some women more likely to develop endometriosis", said Dr. Krina Zondervan, lead author of the study and research fellow at the University of Oxford.